To me UC2 didn't change the industry the first time so no to the thread-title. UC2 was a very good game, one of the best this gen, especially the presentation, but in terms of gameplay I think it didn't change that much. Sure, some games were inspired by it and it set the level very high for polished games but that's it (for me).
Considering TLOU this game could change something, yes. It looks really interesting storywise, in terms of gameplay and presentation. So ND could perhaps change the industry but this will be cross-gen, it will have more influence with nextgen than this gen. ND is a very good developer and Sony can be proud of them.
I still have to get used to this type of games, though.
I said it in another thread: I hope Sony offers Gaikai-clients for more than just Sony-platforms so I can play it sometime in future.
