sth88 on 06 May 2013
Skies of Arcadia is probably at the top for me; I've beaten that game at least 6 times, and at 40-50 hours per playthrough, that would be roughly 240-300 hours; that doesn't includes the three or so times I've started a playthrough of the game and not finished it (including one time I stopped right before the final battles).
Mass Effect 2 is a close second; I've beaten that game 6 times, and I'm about half-way through my 7th playthrough right now (which I'm doing because I'm only a few achievements away from getting all of them, including the ones for the DLC).
