what game do you think will have the biggest impact on the industry?

[HoloDust]

I think what's David Cage is trying to do with Beyond (and Heavy Rain before that) might in the long run influence the industry quiet a bit - there is untapped market of non-gamers out there who would be willing to try out that sort of interactive fiction (with better writing of course), so I see those and similar games as a good first move toward expanding the current market.