ironmanDX on 26 April 2013
Destiny. More so than others mentioned above because it's going to launch in on the nexbox and ps4 also. It will be an mmo and it will be played again and again as even the next gen grows old just like Wow has on pc but probably to a lesser extent. Games coming out late this gen will be great I'm sure but will not have the lasting effect or appeal because of the new generation of consoles.
Edit: A hd Zelda too would be great and have a large impact too if it is made right. 
fingers crossed.
