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I kinda consider Super Mario World to be "Super Mario Bros. 4", or even NSMB Wii. 

But if you mean a brand new mainline sidescrolling Mario game that has an entirely new universe, and not recycled content (ahem, NSMB), then yes I agree, I can see Nintendo doing that, as well they should. The game would be a goldmine that would ignite Wii U sales, similar to how NSMB Wii reignited Wii sales in late 09.