Just bought this the other day. I didn't know what to expect, since I haven't researched the series at all. I just knew the Japanese seemed to like it. Well, now I can see why.
The art style is beautiful; the story is compelling and dark (though transparent at times); the humor scattered throughout is mature and subtle; the puzzles can sometimes take serious time to decipher (if you're like me and try your hardest to get them right in one shot); even the easier puzzles are still entertaining; there's plenty of exploration during chapters; and the Professor is so likeable that you really want to be his friend.
There is only one thing I would change in this game: I don't think being able to tackle puzzles you missed or failed should be as easy as it is. I think the replay value would be thousands of times more if this aspect was removed. I've only missed two puzzles so far, but it didn't even matter.
All-in-all, this game is perfectly suited for the DS. I can't wait for sequels to come stateside!
My End of 2008 Hardware Predictions (console only):
Wii : 50 million
360: 28 million
PS3: 24 million
These predictions were made on January 3rd and won't be revised