With all due respect, Native Americans would've still been killed like they were in reality.
Maybe it'd taken a little longer, but the difference in technology was massive. South American Natives like the Aztecs were a lot more advanced in their society and technology then North American Natives and they still had absolutely no chance. Guns, artillery, navy, professional armies, structured leadership and industrial manufacturing supporting it all; the unexpected side-effect of the European diseases just did most of the work for the colonists. The colonists were there for the land's resources, they didn't care about the indiginous people. If plague hadn't killed the Natives first, Europeans would've took whatever the area had to offer anyway.
Realistically, I'd be the same if a Warp-Drive capable Alien species decides they want to colonize Earth. Given they aren't stupid enough to not check if they'd die in our atmosphere, we'd be whiped out pretty quickly too.
@ SethNintendo: I agree the Human species doesn't add a whole lot to wellbeing of the Earth and what it has to offer. However, rest assured. Our presence here on this planet is only a tiny spec upon it's life. A fraction of a second minorly disturbing the normal flow of things. There isn't anything we can do to this planet that won't be reversed in a millenium after we're gone.







