I'm going to say no.
The whole appeal of the Wii was that "getting off the couch" and playing with grandpa/kid sister/mom etc. was so unique and different that it drove system sales through the roof. Then Nintendo hit the jack pot again by getting to fitness gaming first.
Wii U has none of that, it's just a regular console with a screen on the controller.
It will sell like the GameCube or N64, they can release all the Mario and Zelda games they want, it won't change that much IMO.
Wii U simply doesn't have the same appeal with casuals and there aren't many people even if they like Nintendo who are willing to buy one console for Nintendo games + mediocre third party support.