It started elsewhere, but I thought it was pretty much confirmed to be true. At least, it was widely reported as such.
It was a SurferGirl, was it not?
anyway, here's my idea:
Dr. Mario, MD.
Mario meets Trauma Center with a few added twists: Mario's out to make the most money doctoring possible, and what's the best way to do that? Injure people, then treat them! Features mini-games such as "blow up Wario," "impregnate Peach," and "throw Luigi off a cliff."
Also, you've got skin in the game, because every time you mess up doctoring, you go to court, and have to defend your ass in a high-stakes medical malpractice suit. It's three games in one!
Monster Hunter: pissing me off since 2010.