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You can make a good argument that Master Chief is a bigger bad-ass than Samus and a better soldier and in many ways more terrifying, but Samus doesn't even operate according to the same laws of physics.

All of her powers are extremely radical and videogame-rooted.

Master Chief's own power armor is relatively hard sci-fi.

It's very difficult for hard sci-fi to win out over video game lunacy. Samus would win this fight.