Definitely wouldn't work as well as with Smash Bros for several reasons
1: Smash Bros is less graphically intensive. Brawl (sans textures and resolution issues, i'm talking more strictly in poly-count) was clearly "good enough." Metroid Prime was a lavishly rendered game, the kind of thing where the Wii U/3DS difference would be easily, instantaneously noticeable in Wii U's favor.
2. It's easier to differentiate the Smash Bros experience. You can put the same basic game down on two platforms, and then change up some characters or some game modes and create an experience that is different enough, and do so easily. A Metroid game of any sort (let alone a 3D one likely to be assest-heavy) would be hard to differentiate.
Monster Hunter: pissing me off since 2010.
