I think that it will probably do between 70 and 130 million.
It all really depends on things we know nothing about.
It's an upgraded Wii with a tablet featuring a unique interface. I think that alone with the typical Nintendo support will carry them past 70 million. Pricing will be a factor; but so will software. Nintendo really needs to hit the market with more unique types of software that are untraditional in gaming; Wii Fit is a very good example of this done right; but Nintendo should have released more versions of it. They should expand that market on the Wii U - and make sure to secure more Just-Dance-like content.
That on top of traditional franchises like Mario, Zelda, DKC, Kirby, Kart, and Smash.
I describe myself as a little dose of toxic masculinity.