i like this thread. Let's try to keep it going.
As for Super Mario, I don't think its an accurate predictor of how many systems will sell lifetime. If its included in a whole aggregate games, then yes. But by itself? No.
And Crazzyman's argument that DMC/MGS/GTA4 being multiple system movers may be true, but you must also account for the fact that the DMC/MGS/GTA4 crowd might be all one in the same and that a MGSboy, as it were, is more likely to buy the other two games and that doesn't necessarily mean that those games will expand the market to n00b players. Though buying multiple games for one system is never a bad thing-- that's how Sony will eventually make a return on its investment.