2006 : Wii sports(I had to include this major killer-ap)
2007: Call of Duty 4
2008: Mario Kart wii
2009: New super Mario Bros wii (Uncherted 2, depending on my state of mind)
2010: God of War 3
2011: Not a great year for gaming. I'll go with MW3(King of Fighters 13). If the developers of Uncharted 3 had kept a little bit of the Narrative to themselves and given us at least a final boss, it would have had a chance.