I suppose Metro: Last light is a tad big for this list, but considering the genre it's in I would consider it a dark horse.
Grim Dawn might surprise people I think made by some of the guys that made Titan Quest it should be an interesting hardcore Hack & Slash that may be ignored in the hype for DIablo III and to a lesser extent Torchlight 2. It may miss 2012 tho...

War of the Roses sounds like it will be a new take on Medieval combat, with it's team based persistant multi-player (it's got singleplayer as well) and realistic combat.

Oh and Warlock: Master Of The Arcane, AKA a Civ knock off but with wizards

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