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All the Magnum style weapons in the Resident Evil games, they used to obliterate heads and take down bosses with minimal effort.

The M40A3 in Call of Duty 4, whenever I used that weapon I became one with it, it had such a great feel.

The SAA in Metal Gear Solid 3, being able to spin a gun on your finger, then bounce a bullet round a corner was pretty epic.

The Fat Man in Fallout 3, or even better, the Fat Man that shoots multiple nukes. This weapon was ridiculous, you had the ability to launch nukes at people and reduce them to cinders, it's insanity.