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Each year in the US, more than 40 million used cars are sold. If we assume that the average price of a new car is about $20k, that would mean car manufacturers are losing 832 billion dollars per year to "second-hand sales." That's $832,000,000,000 per year.

Source: http://answers.google.com/answers/threadview?id=146894

The situation for houses is even "worse." Each year in the US, about 5 million existing homes are sold. If we assume the average price of a new home is about $200k, that means home manufacturers are losing about a TRILLION dollars per year to "second-hand sales."

Source: http://www.realtor.org/press_room/news_releases/2011/08/july_ehs

Oh, the tragedy!