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I'm 30 hours in and going stealth all the way. I'm taking out everyone by knocking them unconscious and hiding the bodies. Knocking out 2 guards at once with the reflex skill does wonders. I only rarely use the tranq rifle or stun gun. No problem with ammo since I don't use any.

It takes a lot longer though, having to stake out each room and figure out the order in which to take out the guards.

When I get bored I let a turret or robot do the work for me. Carry a hacked turret around and put it in a door way, easiest way to clear a path.

I could just walk by everything by now with max cloak, silent running/jumping and tons of money to buy instant door hacks, nuke software etc. But exploring and hacking is more fun.