I have no idea how far I am through the game at this point (I'm like 18 hours in?) but I only have a tranq rifle, a stun gun, and a badass 10mm that murders anything if I feel like someone needs to get shot quickly. Also, apparently you can head shot with the tranqs.
Tag(thx fkusumot) - "Yet again I completely fail to see your point..."
HD vs Wii, PC vs HD: http://www.vgchartz.com/forum/thread.php?id=93374
Why Regenerating Health is a crap game mechanic: http://gamrconnect.vgchartz.com/post.php?id=3986420
gamrReview's broken review scores: http://gamrconnect.vgchartz.com/post.php?id=4170835