Well:
1: If Dust 541 can succeed in combining the appeal of an online shooter with that of an MMORPG, I guess it has the potential. I don't think it will, but it is a possibility at least.
2: Little Big Planet. I think it has that kind of potential and focusing on the local multiplayer aspect of it will probably help it go there.
3: Just make an improved Eyepet for the Vita.