If we assume that Wii U will get most of the future multiplats, i'd say Soul Calibur 5, maybe BioShock Infinite.
See, i tend to buy my games based on what's available when, set against those games i determine to be absolute must-haves, and i'm actually not that picky, so i'll buy whatever looks good, likely...
Oh yeah, of the confirmed ones, Ninja Gaiden looks pretty neat.

Monster Hunter: pissing me off since 2010.







