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I run it in high settings, with LOD distance at Far, ubersampling disabled (I don't know what it does ^^). In game, I have 60 fps on a fixed image, and not lower than 40 fps in motion/combat (in Act 1 atm).

I tried in ultra settings, 20 fps max, 15 average

I have a Sapphire Radeon HD 5870 1GB, a Core i7 950 3.1GHz, and 6GB of DDR3. Resolution 1920x1080. 

Loading times are fine (much lower than ME2).