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Played about 2.5 hours worth, an hour straight at first with no real issues.

 

When I turned it on with the slider at full, about 20 seconds after the first 3D effects came on I felt a tension in my brain that does often preclude headaches.  It spooked me, I turned the 3D off an it went away instantly.

 

Then I think I screwed around with the slider for a few minutes but ultimatley I just left the 3D on full and at some point forgot about the tension.  I never ended up with a full blown headache.