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Resident_Hazard said:

Looking at my game systems, the only one I have with two inputs in the old Sega Master System which could take the Master System cartridges and has a slot for TurboGrafx-like Hu-Cards.  The later version of the Master System dropped the card slot.  

Outside the original Mark III/Master System, the only one I can think of is the Saturn, which had both a CD-ROM drive and a cartridge slot.  Of course, no games were ever released only on cart, it was mainly used for memory units and RAM upgrades (and originally intended for MD backwards compatibility, though that got scrapped).  At least one game (KOF 95) had a dual media release though, using both CD and cart in tandem.

Gaming oriented computer formats like MSX or the earlier SG-3000 often had various media inputs though (game cards, game carts, floppies, etc). There were also combined platform units for consoles released though, like the Turbo Duo, Twin Famicom, X'Eye or Genesis CDX.  Originally Nintendo also wanted to put two DS card slots in the DSi, though they decided against it due to the added footprint.