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Packie said:
ithis said:

What if I killed Patches the Hyena in 2-2? I mean he was rude and tried to trick me. I was surprised that he didn't fight back, but that was after the final blow... 

Well, it's up to you but I recommend not killing patches because later in the game he became my most important vendor for healing herbs and heavy arrows in the nexus.

That and the Mephistopheles quest where you get a colorless demon's souls