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Tough to call, they are my two favorite cartoons. I love the wittiness and random humor of family guy, and I love the topical/political and vulgar humor of South Park that usually leaves you with an intellectual message in a funny way.

I guess I would say I prefer OLD family guy (like the late 90s - early 200s), and NEW South Park (early 2000s to present). I feel family guy lost its witty more subtle humor in the older episodes that brought much of its appeal to me, and replaced it immature, off the wall fart jokes type of comedy. South Park I feel was a bit too immature at first and didn't fully develop its true character and didn't really get smarter until roughly into season 4.