I think it all depends on the reviews. If the new Zelda gets Mario Galaxy 2 kind of reviews and great word of mouth then I think that it can sell on comparable levels to DKCR and SMG2. Wii owners will be hungry for a new top-quality Nintendo game.
Lets just hope this game doesn't get the kind of reception that Metroid: Other M did.
Most anticipated games of 2011:
Uncharted 3,Legend of Zelda: Skyward Sword, Rocksmith
Modern Warfare 3, Super Mario 3D