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GTA IV could have an advantage here being multiplatform but i don't know it's too close to call. Halo 3 might end up selling more copies than GTAIV on the 360 platform, but sales from PS3 GTAIV will put them overall ahead of Halo 3. i think Pokemon Diamond will probably be the best selling game since it's got the head start. by the time those games come out, Pokemon will have sold more than 3 million copies and i'm sure the holiday season will boost sales even more. then of course you have Madden. that game will always sell alot of copies.