Being that Zack and Wiki was low budget for a Wii game I can't imagine that it would require that high of sales to break even or turn a profit. I think the real important thing is whether Capcom is happy with the sales ...
Historically, new IPs perform relatively poorly and even worse when they're in a new or unusual genre. Companies that have been successful with introducing new IPs are either remarkably lucky or persistent; if you look at successful series you will see that quite a few ended up having break out success with their second or third game in the series.