Don't fool yourself. Skyrim is by far the biggest favorite.
Uncharted 3 will come closest quality/review-wise but it will suffer from feeling "more of the same", and it suffers a little from being exclusive.
Mass Effect 3 will get superb reviews and is multiplatform but suffers from an early year release and memory fade.
Meanwhile there's a whole 5.5 years between the last Elder Scrolls (Oblivion who also won Spike's GOTY) and Skyrim.