A Samus-free Metroid has it's benefits, but to be honest I'd prefer if they just waited a few years then make a Metroid Prime game or a 2D Metroid game with pointer aiming, which ignores the existence of Other M. Perhaps blatant ret-conning is a bit unfair to those who enjoyed Other M, as much as I'd love to see it happen but it should certainly find a way that Other M has no implications upon the new game.
If Metroid Prime does return they need to think hard about how to do it, don't simply make it even more like a first person shooter, find a way to expand upon what is there without dropping the main Metroid values.
A game I'm developing with some friends:
www.xnagg.com/zombieasteroids/publish.htm
It is largely a technical exercise but feedback is appreciated.







