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Bodhesatva said:
I'll go with a shocker -- by which I mean "not a Wii game" -- and say Microsoft will secure Mass Effect 2 as an exclusive.

Im going to disagree, since bioware was eatin up by EA I believe mass effect will be multiplatform, encompassing the 360, the PC, the Wii, and maybe even the PS3

 - As to biggest new title announced, im going to say Wii Sports 2 - or maybe Wii Play 2 where Nintendo will take advantage of Johnny Lee's demonstrated Wii ability (meaning his demonstrating that the Wii can do what it can) and that will totally blow people's freakin minds when the "mass" public sees it. (Picture these kids infront of a demo machine knocking eachother over.