My must-haves:
GT5 - Looks awesome, Prologue was sweet.
Enslaved - I loved the storytelling in Heavenly Sword, and even if the gameplay sucked in Enslaved, it would still be up high on my list for that reason alone.
LBP2 - Awesome? I think so.
PS Move - It's cheap for pre-order, so now is the time!
DeathSpank: Thongs of Virtue - Loved the first one, and I'm already getting a sequel! Fuck yeah!
Maybes:
Assassin's Creed: Brotherhood - We'll see if I feel like playing another AC.
Heavy Rain: Move Edition - If I have the money...
Resident Evil 5: Gold/Move Edition - A cheap game for Move, could be worse!
L.A. Noire - If it ever releases...
Medal of Honor - Awesome single player campaign in the vain of CoD4? Oh yeah...
Epic Mickey - Looks sweet.
If I get a PC:
Mass Effect 1 2 - BioWare space RPG, 'nuff said.
Metro 2033 - I want to see this game in 3D!
