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It's not like Mass Effect 2 is going to get hugely affected by the lack of ME1... And without really playing the games, I'm guessing that the choices made in ME1 affected ME2, which in turn affects ME3.

I don't think there's going to be any harm done. At least there doesn't have to be unless BioWare makes it so which would be very lame. Which seems to be exactly what they're doing with Dragon Age 2 though.