Brawl by a very large margin at about 350hrs
Wii Fit/Wii Fit Plus would be next creeping upwards of 200hrs
After that there's several around 108hrs including Wii Sports, Mario Kart, Mario Strikers, CoD:WaW, LoZ:TP, GHIII
close to 90hrs each are Godfather and Fire Emblem
Anything else is 2-50 hrs







