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At first I would say close call, but considering PS3 's userbase and software sales I expect Mario Kart to win by a large margin. However I expect a GT6 to outperform GT5. I believe Mario Kart Wii will be the best selling Mario Kart yet due to a bigger userbase and online play.

Mario Kart Wii: 12 million
GT5: 7 million
GT6: 9 million