Judging by their Wiki article these are the projects Retro worked on prior to Metroid Prime that were eventually cancelled.
"Retro Studios was developing several video games for the Nintendo GameCube which eventually got canceled. These included an adventure game called Raven Blade; a driving game called Car Combat; an American football game called NFL Retro Football; and an unnamed action-adventure game. Slow development and the offer to develop Metroid Prime were the main reasons of cancellation."
Just as some small indicator of what territory they've tried to cover before.
If they were to work on an existing IP, I think F-Zero would be very likely. Starfox would be awesome, however.







