I can't pick one.
Gigyas, Earthbound
Ganon, OoT
Zeromus, FF4
Kefka, FF6
I don't know his name, but the boss in Contra III where you have to climb the walls and ceiling to avoid his attacks (I LOVE THAT FIGHT)
I remember those fights the best (go SNES, best system ever!)
If I HAD to choose one, Ganon, but mostly because I did a 3-heart challenge in OoT. Try it sometime, play through the whole game without picking up any hearts or heart pieces (it's one of the only Zelda games that allows you to do it). For easy mode, you can use fairies, for hard mode, only potions/milk, and don't get the defense upgrade. Playing through all of OoT with that was one of my most cherished and memorable gaming experiences (I played semi-easy mode, 1 fairy, but rest potions, no defense upgrade).
Please note I did this with the N64 version, not sure if the Master Quest will let you leave dungeons without picking up hearts.







