If GT5 comes out this year, than it's a clear winner. The same goes for The Last Guardian. If not, it's going to be close.
UC2 = GoW3
And the rest is close to each other. We don't have anything yet confirmed except for these big hitters which are already out: MAG, Heavy Rain, God of War 3 (almost).
MY HYPE LIST: 1) Gran Turismo 5; 2) Civilization V; 3) Starcraft II; 4) The Last Guardian; 5) Metal Gear Solid: Rising