The lack of a big announcement was the biggest announcement? I could actually see Cammie coming on stage and saying that :P
We already basically know what Nintendo will throw at us for the holidays and that's Wii Vitality/Wii Relax (whatever it's going to be called) and Zelda Wii. I think E3 will be pretty big this year, my guess it'll include:
- Metroid: Other M on stage demo as the game releases a couple of weeks after E3
- Vitality Sensor final hardware and software
- Retro Studios next title with a tentative 2011 release date
- Pikmin 3 announced with a tentative 2011 release date
- The Legend of Zelda: Wii unveiled with full stage demo and trailer
- Next generation Pokemon titles shown off
- A couple of brand new Nintendo IP's for DS and DSi to revitalise lagging software and hardware sales
Probably a couple more little things for WiiWare and DSi but that'd probably be the bulk of it.