If DSi XL is coming out in this quarter as they say it is, then have to give it a hype push. That should be the major thing.
Beyond that, they'll probably give some release dates and let the press play a couple key games for Wii/DS/Digital stuff.
Wii:
Galaxy 2/Metroid release dates. Probably playable.
Monster Hunter 3 playable
Sin & Punishment 2, and maybe a few others will show up too.
Probably some hype for stuff like NBA Jam, Epic Mickey and Red Steel 2.
DS:
DSi XL centered mostly
Pokemon HG / SS
Golden Sun, maybe a couple third party games.
VC/DSiWare/WW:
Sonic the Hedgehog 4
Max & The Magic Marker
Could see a couple third party games announced for WW/DSiWare/DS/Wii too. Personally, I'd like to see what DS would do with a price drop in the USA, but there is no reason for it yet since PSP is more expensive and performing much worse in comparison.
People are difficult to govern because they have too much knowledge.
When there are more laws, there are more criminals.
- Lao Tzu