Yokoi: it was his genius that saw the opportunities of using 'mature' (read: old and cheap) technology to pioneer the market that Nintendo came to dominate (beginning with the Game & Watch) and a philosophy that, when Nintendo has followed it (e.g. G&W, NES, GameBoy, DS, Wii) has made the company the force it's been throughout its existence.
It is truly a shame that his career had to be marred by the Virtual Boy when he, ironically, followed his own philosophy to his doom. (That being said, Mario Clash is still an amazing game and I'm glad the VB existed if only for that.)