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I loved both games, but if we are not counting multiplayer Galaxy easily wins for me. I've played through Mario Galaxy multiple times, whereas after beating NSMBWii I haven't played it again. In fact as soon as I was done with NSMBWii the first time I went back to playing Galaxy again.

If we were counting Multiplayer it would be a lot closer, because NSMBWii was the most chaotically fun game in multiplayer. Peoples' reactions when you throw them off a platform or bounce on their head, etc. is priceless.