Alright, I'll throw some out, nice to have it all on one thread (for better or worse, if they suck)...
All predictions are for the end of 2010 (week ending Jan 1 2010):
1) Wii - 86.5m
2) DS - 149m
3) X360 - 47.5m
4) PS3 - 43.5m
5) Top 10 selling software by yearly VGC data, will consist of (in my best effort for order):
Wii Sports, NSMB Wii, Wii Fit+, Pokemon HG/SS, WSR, Halo Reach, GT5, Wii Vitality, CoD7(360), MK Wii
6) 360 version of Modern Warfare 2 will be > 1m under Halo 3
7) Halo Reach will sell more than GT5
8) Epic Mickey (Wii) will sell over 1.5mil
9) In the Americas, FFXIII for the 360 will outsell the PS3 version
10) Wii will outsell the PSP in Japan for the year
11) In Others, GT5 will become the top selling PS3 title (overtaking MW2 and GTA4's lifetimes)
12) In Americas, GT5 will not make the top 10 selling software by yearly VGC data (even without Wii Sports)
13) Mario Kart Wii will outsell SMG2 for the year (edit: had 2 #12's, fixed)
14) Mario Kart DS will hit 20mil
15) DQIX will hit 6mil, MH3 will hit 2mil (hits in the west!)
16) KH3 will not be announced! *shock*
Well, that's enough I think. Some risky ones here and there, we'll see how it goes.