I don't drive but I do run. I also can't stand FPSs for this reason as well. I think it has something to do with immersion, in first person mode of games, If a character looks to the left, my brain feels my body should move to the left in some capacity, if it doesn't my senses kinda lurch and disorientate me making feel sick.
Might be different for everyone else but that's how it is for me and Mirror's edge is a fine example why I can't handle these things, this is why I always play things in 3rd person rarely in first.