Resident Evil 5 - Exact same reasons disolitude said.
Fire Emblem: Radiant Dawn - Boy, people are going to hate me for this. I don't think it's a bad game, not at all, but it didn't interest me nearly as much as Path of Radiance did.
Prince of Persia - Total departure from the Sands of Time trilogy disappointed me, and then when I got to try the game it was so ridiculously easy that I haven't touched it for more than an hour since I got it last christmas.
Dragon Ball: Raging Blast & Marvel: Ultimate Alliance 2 - Solid games, but I deduct points for them for actually reducing the rosters of their predecessors.
Sonic 06 - I don't think I even need to justify this one.
EDIT: Oh, and MGS4, but I've gone on and on about how I don't like that game so I think most people already know that by now.
