TWRoO on 12 November 2009
Errm played Mario Kart Wii the most, but I guess you mean something that actually has a start and a finish.... and how many times I went through it... if so then probably Resident Evil 4:Wii, which I think I have played through about 12 times (though for reference, I have played through Zelda:TP only about 5 times but racked up about the same number of hours)
