Are There Any Good Lonely or Sad Games on DS?

[MidnightRider85]

Are there any good Sad or Lonely games on DS?  If so what are they?  By Lonely games I mean games like Ico or Shadow of the Colossus or the upcoming Fragile and Cave Story for Wii and probably The Last Guardian for PS3.  EDIT:  The World Ends with You probably fits the criteria.  Are there others?