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I don't know what the connector looks like on your video card. If it is like most other cards then that cable won't work.
you will need one with a smaller head on one side.

here's a link to a pic of the cable
http://www.evga.com/products/enlarge.asp?PN=W000-00-000070&I=1

you won't have to open the box to use the headphones. Just change the audio device in the preferences before you start playing any sound.