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Euphoria14 said:
Well I know for a fact they do not respawn in tunnels, dungeons, forts, towns, etc. If enemies spawn at all they just spawn in the Wasteland. That part I love, but having an empty wasteland makes me wish I had some DLC right now although I am at Vault 87, no idea how much game I actually have left.

Where is the last place I can save before I hit the point of no return?

You're approaching the home stretch: I'd say if you only do the main quest you're an hour from finishing. As for the last time you can continue from, it's fairly obvious: you'll be asked if you're ready, etc.